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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Milk Thistle Phospholipid Proprietary BlendMilk thistle extract (fruit) [providing 480 mg silymarin, 180 mg silybin, 48 mg isosilybin A and isosilybin B], phospholipids
760 mg
**
SILIPHOS® phytosome milk thistle extract (fruit) [providing 47.52 mg silybin]
160 mg
**
Top Medical Research Studies
9
Silymarin improves liver protection
Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress.
High potential therapeutic relevance
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
8
Lipid balance and liver protection
Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids.
Effectiveness varies by condition
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Read More
8
Silymarin showed enhanced liver protection
Evaluating the therapeutic effect of different forms of silymarin on liver status and expression of some genes involved in fat metabolism, antioxidants and anti-inflammatory in older laying hens.
Relevant for poultry health studies
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
Read More
Most Useful Reviews
9.5
Detox support
This supplement is excellent for liver detox while undergoing treatment for Lyme disease and mold toxin illness, which can adversely affect liver function. My ALT levels were consistently high, but after starting milk thistle, they returned to normal. My doctor was very impressed with the results, and I highly recommend this product for liver support.
Read More
9.5
Normal enzyme levels
This supplement has been fantastic for controlling my liver enzymes. After struggling to detox from Lyme disease and mold toxin illness, this product has proved to support my liver well, and my enzyme levels are now within the normal range.
Read More
8.8
Disease management
After curing Hepatitis C, I relied on this product and other liver protective supplements to keep liver disease in check until qualifying for medication. It was worth every penny, only requiring one gel capsule daily to support my liver health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
9
Silymarin improves liver protection
Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress.
High potential therapeutic relevance
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
9
Silymarin improves liver health in mice
Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice.
High relevance to liver disease treatment
We investigated how silymarin, along with other natural compounds, affects non-alcoholic fatty liver disease (NAFLD) in mice. Over 16 weeks, mice on a high-fat diet received silymarin supplements, which significantly improved liver health and reduced fat buildup.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Read More
9
Effective liver protection with nano-SM
Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L.
High relevance for liver treatment
We investigated the potential of a specially formulated version of Silybum marianum, known as nano-SM, to combat liver damage caused by a compound called 17α-ethinylestradiol (EE).
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
Read More
8
Lipid balance and liver protection
Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids.
Effectiveness varies by condition
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Read More
8
Silybum marianum aids liver health
Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis.
Moderately relevant liver treatment insight
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Detox support
This supplement is excellent for liver detox while undergoing treatment for Lyme disease and mold toxin illness, which can adversely affect liver function. My ALT levels were consistently high, but after starting milk thistle, they returned to normal. My doctor was very impressed with the results, and I highly recommend this product for liver support.
Read More
9.5
Normal enzyme levels
This supplement has been fantastic for controlling my liver enzymes. After struggling to detox from Lyme disease and mold toxin illness, this product has proved to support my liver well, and my enzyme levels are now within the normal range.
8.8
Disease management
After curing Hepatitis C, I relied on this product and other liver protective supplements to keep liver disease in check until qualifying for medication. It was worth every penny, only requiring one gel capsule daily to support my liver health.
